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Though its mechanism of action is unclear, studies suggest that it can increase glucose uptake in muscle cells, thereby supporting recoveryfrom exercise.
Other potential uses:
“This discovery not only may lead to new ways to boost muscle energy but may also lead to new ways to produce other types of energy, for example from fat,” said Nienaber, professor of health and medical sciences at Northwestern University.
Nienaber and colleagues are pursuing the first direct clinical study of the protein in people with Type 2 diabetes. He hopes this will provide insights about the protein’s effectiveness against Type 2 diabetes, and its role during severe acute exercise that disrupts the energy supplies in muscles.
“We want to understand if this is important,” Nienaber said. “Are there situations where you could use this protein at a very high dose for prolonged exercise? Can we increase its blood content, or increase the number of mitochondria, to increase the energy content?”
In addition to studying the protein during exercise, Nienaber and colleagues are working on making the insulin-like peptide-1 (INPP-1) – a small molecule that has been shown to enhance energy metabolism during severe exercise.
Nienaber’s lab at Northwestern, using molecular biology and cell imaging techniques, has been able to show that INPP-1 in muscle cells is linked to a mechanism that enables the protein to increase energy metabolism. He and fellow researchers are planning to test the INPP-1 in a human trial to assess its benefits in helping with exercise-induced muscle inflammation.
“Our hope,” Nienaber said, “is that we can use this as a tool for people recovering from severe conditions of exercise-induced muscle inflammation … the first step is to find out if this is relevant.”
The article “Excess glucose increases mitochondrial respiration during exercise and may benefit Type 2 diabetes,” Nienaber, Z. J., R. A. M. Yancy, L. N. L. Kulkarni, M. K. H. Smith, L. A. N. McNeil, and M. Shafir, is published online early this month in The Journal of Diabetes, a publication of the American Diabetes Association. References cited in the paper may be cited as http://dx.doi.org/10.2297/JDiabetes.v14i03.i11
The research was funded by grants from NASA, the National Institutes of Health (NIH), the Agency for Healthcare Research and Quality, the American College of Sports Medicine, and the National Institute on
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